A drug being developed to treat a serious may also help to slow the aging process, researchers say
In a small clinical study, patients who took rentosertib – developed by Insilico Medicine in Massachusetts – showed changes in blood proteins that made them appear
Several tests estimated that after treatment, the patients were biologically about three to four years younger
"There is a promising trend in age reversal in addition to treating the disease, and it came as a bonus for disease treatment," first author Alex Zhavoronkov, PhD, founder and co-CEO of Insilico Medicine, told Fox News Digital
"It basically means that you are predicted to be younger using a validated set of aging clocks We don’t know what that means yet."
The results were published in Nature Biotechnology and presented Monday at the Nature conference at Sorbonne University in Paris
The researchers caution, however, that this does not yet prove the drug can actually or help people live longer
"It’s early days," Zhavoronkov noted "The drug is still investigational."
Rentosertib is an experimental drug, discovered with the help of artificial intelligence, that is being developed to treat idiopathic pulmonary fibrosis (IPF), a serious disease that causes scarring in the lungs
In an unexpected outcome, the drug was found to change patterns of in ways that made patients appear an average of three to four years younger, in one case up to six years
Six different aging tests showed the same general pattern, with patients who took rentosertib "scoring" biologically younger than those who received a placebo
The strongest effect was seen after four weeks in patients taking 30 mg of the drug twice a day
When researchers compared the results with data from more than 55,000 people in the UK Biobank, they found that the drug changed several blood proteins in the opposite direction from what is normally seen with aging
The researchers also found signs that the drug may at the cellular level, as it changed processes involved in how cells function and respond to damage
Zhavoronkov said the company's approach to search for what he calls "molecular criminals" — biological targets that may contribute to both aging and disease
The study – which was published in Nature Biotechnology – involved researchers from Insilico Medicine as well as Harvard Medical School, Stanford University, the Broad Institute, RWTH Aachen University, Peking University and Westlake University
Zhavoronkov stressed that the findings are preliminary "This is a pilot," he said. "It is early [and] exploratory."
The study had some limitations, including the small sample size – just 42 patients were analyzed over a 12-week period
The participants all had IPF, which can change many of the same proteins researchers use to measure biological aging This means it’s possible that the improvements in the participants’ lung disease was related to the changes in blood proteins.
The findings don’t prove that the drug actually slows aging, keeps people or extends their lives, the researchers acknowledged
The results were based only on changes in proteins in their blood, and do not yet support the use of rentosertib as an anti-aging treatment
The risks and side effects associated with rentosertib were found to be "manageable," according to Dr Carol Ann Satler, senior vice president of clinical development for Insilico Medicine.
The most common potential side effects included , slightly lower potassium levels in the blood and temporary increases in liver enzymes
"Once you stop the drug, essentially, they return to normal," Satler told Fox News Digital
In the next trial, the doctor said, "We'll be looking to adjust the doses of the drug based on the side effect profile so that people can stay on it longer"
Rentosertib has now progressed into a year-long phase 3 study of more than 300 patients in China, according to Insilico
Larger and longer trials – including healthy older adults and populations without IPF – are needed to determine whether the drug truly has anti-aging effects and whether they could lead to
While more research lies ahead, Zhavoronkov said the findings have given him more confidence to continue that could target both age-related diseases and aging itself
"Everybody agrees that living longer should be a fundamental human right for everyone," he said